Research and Developments

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July 19, 2018

Emixustat Found Ineffective

Posted in: Latest News, Research and Developments

The drug Emixustat has been in Phase 1/2 trials since 2008 for treatment of dry macular degeneration. Disappointingly, the drug has now been found to be ineffective at reducing the growth rates of geographic atrophy (GA) in patients with age-related macular degeneration (AMD). Preclinical analysis of Emixustat indicated that it inhibited the activity of the
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May 19, 2018

Summary of Research and Development — 2018

Posted in: Health and Nutrition, Latest News, Research and Developments, Therapies, Treatments, and Procedures

Transcript of a presentation to the International Low Vision Support Group June 2018 Dan Roberts, Director Select this link for audio-visual format INTRODUCTION This is our 13th annual summary of leading research and developments occuring during the past 12 months in the fields of blindness and low vision. Sources for further information will appear beneath
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April 25, 2018

Müller Cells Might Be Re-programmed to Become Sight Cells

Posted in: Latest News, Research and Developments

Degeneration of photoreceptors (rod and cone cells) is a leading cause of vision loss. Since there are no effective treatments to restore vision once photoreceptors are lost, photoreceptor regeneration has the very real prospect of alleviating blindness in these eyes. To that end, a recent innovative study has demonstrated the possibility of reprogramming Müller glial
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April 25, 2018

Mediterranean Diet Lowers Risk of AMD

Posted in: Health and Nutrition, Latest News, Research and Developments

Studies in France and the Netherlands have shown that a Mediterranean diet is linked to a lower risk of age-related macular degeneration (AMD). Researchers investigated the effects of such a diet on a large sample from subjects from two population-based prospective studies. The diet consists of more than median intakes of vegetables, fruits, legumes, cereals,
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April 16, 2018

Will Driverless Vehicles Be Accessible To The Visually Impaired?

Posted in: Daily Living, Latest News, Research and Developments

by Dan Roberts Autonomous (driverless) vehicles are on the way. The technology is already in place, having been successfully tested for several years under every city and highway traveling condition. Many automakers report that their new cars are now being equipped for driverless operation, so the change-over will be easy when the time comes. And
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March 22, 2018

NIH Launches International Study of AMD Progression

Posted in: Latest News, Research and Developments

Natural history investigation will deploy latest advances to identify biomarkers, targets for early therapy A new clinical study led by the National Eye Institute (NEI), part of the National Institutes of Health, will follow 500 people over five years to learn more about the natural history of early age-related macular degeneration (AMD). By using the
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March 20, 2018

New Stem Cell Therapy Treats Macular Degeneration

Posted in: Latest News, Research and Developments

A new procedure reported in the current issue of Nature Biotechnology has been shown to be a safe and effective method for introducing stem cells into the retina. Implantation of a specially engineered patch of retinal pigment epithelium (RPE) cells derived from stem cells has restored some vision in two people with sight loss from
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January 26, 2018

First AMD Patient Receives Sub-Retinal Implant

Posted in: Latest News, Research and Developments

(Updated 4/17/18) Pixium Vision has announced its first successful human implantation of a wireless sub-retinal implant in a patient with atrophic dry age-related macular degeneration (AMD). So far, three patients have been implanted with the device, and results are promising. As reported here in October 2017, the implant, called PRIMA, acts like a tiny solar
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December 21, 2017

Apellis Entering Phase 3 Trials for Dry Macular Degeneration

Posted in: Latest News, Research and Developments

Apellis Pharmaceuticals has announced that it has finalized the trial design for its planned Phase 3 program evaluating APL-2 for the treatment of patients with geographic atrophy (GA), aka dry macular degeneration. The Phase 3 program, planned to begin in the second half of 2018, will consist of two identical studies to assess the efficacy
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December 20, 2017

FDA Approves First Gene Therapy for Inherited Retinal Dystrophy

Posted in: Latest News, Research and Developments, Therapies, Treatments, and Procedures

The U.S. Food and Drug Administration (FDA) has approved Luxturna (voretigene neparvovec-rzyl), a new gene therapy developed by Spark Therapeutics, to treat an inherited form of vision loss that can result in blindness.  The most prevalent inherited retinal dystrophies are retinitis pigmentosa (RP), Leber congenital amaurosis (LCA) and Stargardt disease (SD), all of which have
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