Research and Developments

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August 29, 2013

“As-Needed” Injections Are an Option for Wet AMD

Posted in: Latest News, Research and Developments, Therapies, Treatments, and Procedures

Two-year results from the recently-completed HARBOR trial showed that some patients with wet AMD fare as well from Lucentis (ranibizumab) injections on an as-needed basis compared to a monthly basis. The original Lucentis trial recommended monthly dosing until the eye stabilized. The follow-up study, however, found that 93% of patients responded well with an average
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August 27, 2013

Lampalizumab Effective in Slowing Progression of Dry AMD

Posted in: Latest News, Research and Developments

Roche Pharmaceutical has announced positive phase II results from their MAHALO phase II study of lampalizumab (aka anti-factor D). The study showed a 20.4 percent reduction in progression of advanced dry macular degeneration (geographic atrophy) at 18 months. Lampalizumab is designed to inhibit Complement Factor D, a protein that is part of the alternative complement
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August 22, 2013

Support Groups Can Improve Quality of Life

Posted in: Daily Living, Latest News, Research and Developments

by Dan Roberts Researchers have found that facilitated patient support groups can significantly improve visual quality of life (VQoL) for visually impaired people. Twenty-nine groups of up to six patients each were recruited for participation in a “peer group emotional support service” facilitated by trained counselors for a period of six months. Their responses to
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August 21, 2013

Improving Autophagy Function Reduces Drusen

Posted in: Latest News, Research and Developments

by Dan Roberts Researchers at the University of Eastern Finland have discovered that a cleaning mechanism in the center of the retina may be faulty in people who develop age-related macular degeneration (AMD). A cleaning process called autophagy helps clear cellular waste deposits (drusen) that can build up in the retinal tissue. If autophagy diminishes,
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August 15, 2013

Study of aquaporins could hold clues to cataract

Posted in: Latest News, Research and Developments

Researchers have achieved dynamic, atomic-scale views of a protein needed to maintain the transparency of the lens in the human eye. The work, funded in part by the National Institutes of Health, could lead to new insights and drugs for treating cataract and a variety of other health conditions. Aquaporin proteins form water channels between
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July 23, 2013

Disparities in Eye Care Could Cost Some Their Sight

Posted in: Latest News, Research and Developments

Low-income, less educated don’t have same access to preventive treatments, researchers report By Robert Preidt THURSDAY, July 18 (HealthDay News) — Americans with low incomes and education levels are less likely to get eye care, a new study finds. Researchers examined data from nearly 3,600 people, aged 40 and older, who took part in the
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July 20, 2013

Gene Therapy Without Retinal Risk

Posted in: Latest News, Research and Developments, Therapies, Treatments, and Procedures

Researchers have developed a method of delivering genes to the inner layers of the retina without the risks associated with injection into the delicate tissues themselves. This less invasive technique has been carried out successfully in animal models by a research team led by Drs. John G. Flannery and David V. Schaffer at the University
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July 19, 2013

Gene Expression in the Retina Expanded

Posted in: Latest News, Research and Developments

Identifying the genetics of retinal degeneration has become especially important with progress of trials in gene therapy. Investigators have identified more than 200 retinal degeneration disease genes, but still haven’t been able to find the cause of disease in up to half of cases. Now Ocular Genomics Institute has announced that Drs. Michael Farkas, Eric
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July 6, 2013

What Should I Ask My Doctor?

Posted in: Daily Living, Eye Conditions, Health and Nutrition, Research and Developments, Therapies, Treatments, and Procedures

by Dan Roberts Updated July 2013 One of the most common problems encountered by people who are first diagnosed with macular degeneration is what to ask the doctor. The news usually takes us by surprise, and we may have never even heard of the disease before. To compound our confusion, many doctors do not have
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July 6, 2013

What is a Clinical Trial?

Posted in: Research and Developments

(From “The First Year: Age-Related Macular Degeneration,” (Sep 2006) by Daniel L. Roberts) A clinical trial involves direct observation of a living patient to answer specific questions about vaccines, therapies, or new methods. It is designed in four phases, during which rigorous protocols must be followed under FDA guidelines: Phase I: Determination of safety and
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