Research and Developments

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April 22, 2009

siRNA Turns Off Bad Genes

Posted in: Research and Developments

by Dan Roberts (updated April 2009) A new type of anti-VEGF drug called “small interference RNA (siRNA),” is showing promise in its ability to turn off genes that cause wet AMD. A preliminary primate study in early 2004 showed that, at the highest dose used in the study siRNA (formerly called RNAi) “reduced the incidence
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November 20, 2008

Brain Reorganizes to Adjust for Loss of Vision

Posted in: Research and Developments

Atlanta (November 20, 2008) – A new study from Georgia Tech shows that when patients with macular degeneration focus on using another part of their retina to compensate for their loss of central vision, their brain seems to compensate by reorganizing its neural connections. Age related macular degeneration is the leading cause of vision loss
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November 10, 2008

Interleukin-6 and Interleukin-8 Linked to Dry AMD

Posted in: Research and Developments

by Dan Roberts (Updated November 10, 2008) Concentration of two cytokines, interleukin-6 and interleukin-8, have been found in two different studies to be potential biomarkers for incidence of dry AMD. Cytokines are signaling compounds in the cells that are involved in a variety of immunological, inflammatory, and infectious diseases. Janice C. Law, MD, and her
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September 29, 2008

POT-4 for Treatment of AMD

Posted in: Research and Developments

by Dan Roberts (Updated September 29, 2008) Potentia Pharmaceuticals, Inc. announced on March 20, 2007 that it was entering the clinical phase of development of POT-4 for treatment of age-related macular degeneration (AMD). According to the researchers, POT-4, a synthetic peptide, shuts down the complement activation system that can lead to local inflammation, tissue damage
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September 22, 2008

Pearls from Recent Studies on Low Vision Rehabilitation and Psychosocial Issues

Posted in: Daily Living, Research and Developments

Research of interest to the AMD Community as presented at Vision 2008, Montreal, Canada Selected and Summarized by Dan Roberts, Director, MD Support These findings are derived by the referenced authors based solely upon the results of their respective studies. In every case, more research is recommended before final conclusions can be drawn. Pearl #1.
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August 28, 2008

New Dry AMD Gene Found

Posted in: Latest News, Research and Developments

by Dan Roberts As reported in the Aug. 28, 2008 online edition of the New England Journal of Medicine, researchers have found a genetic link associated with dry AMD. That’s the good news. The bad news is that siRNA drug therapy may increase the risk for dry AMD in patients who have that genetic variant.
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June 1, 2008

Summary of Research and Developments in Macular Degeneration: 2007-2008

Posted in: Research and Developments

Compiled and edited by Dan Roberts JUNE 2007 Omega-3 Proving to be Beneficial on Several Fronts Recent studies have shown that Omega-3 fatty acids and fish consumption may reduce the risks of age-related macular degeneration (AMD), Alzheimer’s disease, inflammation and depression. The Age-Related Eye Disease Study (AREDS) Research Group showed that dietary total Omega-3 and
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April 28, 2008

Gene Therapy Breakthrough

Posted in: Latest News, Research and Developments

by Dan Roberts April 28, 2008 According to two studies published in the New England Journal of Medicine*, doctors have, for the first time, used gene replacement therapy to restore vision in patients with Leber’s congenital amaurosis. Leber’s syndrome is a form of retinitis pigmentosa (RP) that affects children and often leads to blindness by
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March 19, 2008

Müller Cells May Restore Sight

Posted in: Latest News, Research and Developments

by Dan Roberts March 19, 2008 Over the past several years, scientists have been taking an interest in certain cells within the patient’s own eyes as having the potential to transform into stem-like (progenitor) cells. Called Müller glial cells, they would then migrate to damaged areas of the retina and replace dead cells, restoring vision
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March 17, 2008

Robo-4 and Slit2 May Team Up Against Wet AMD

Posted in: Latest News, Research and Developments

by Dan Roberts March 17, 2008 “Robo-4” sounds like a movie by Arnold Schwarzenegger, but in this case, it is a link to another potential treatment for wet AMD. Short for “Roundabout,” Robo-4 is a protein receptor found on the surface of blood vessel cells. When it binds with another protein called Slit2, the combination
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