October 25, 2004

Drugs & Supplements With Adverse Effects on Ophthalmic Conditions Drugs

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Drugs & Supplements With Adverse Effects on Ophthalmic Conditions Drugs

This list of drugs is derived from the American Academy of Ophthalmology Syllabus for “Drug-Related Adverse Effects of Clinical Importance to the Ophthalmologist (F.W. Fraunfelder, MD, Instructor). For details about each drug, see the Syllabus.
DRUGS
topiramate (Topamax)
10% phenylephrine pledgets (Neo-Synephrine)
sildenafil (Viagra)
isotretinoin (Accutane)amiodarone (Cordone)
hydroxychloroquine/chloroquine (Plaquenil)
marijuana
tamoxifen
Bisphosphonates:
alendronic acid
ibandronate
pamidronate
zolendronate

Carbonic Anhydrase Inhibitors:

acetazolamide (Diamox)

dichlorphenamide (Daranide)

methazolamide (Glauctabs & Neptazane)

topical Ocular Dorzolamide (Trusopt)

Topical Ocular Prostaglandin Analogs:

travoprost (Travatan)

latanoprost (Xalatan)

bimatoprost (Lumigan)

unoprostone isopropyl (Rescula)

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The following supplements have been found to have a wide range of adverse ocular side effects ranging from dry eye to retinal hemorrhages and transient visual loss, as reported in 2004 by Frederick W. Fraunfelder, M.D. to the World Health Organization, the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects. For more information, see “Ocular side effects from herbal medicines and nutritional supplements” in the October 2004 issue of the American Journal of Ophthalmology.
SUPPLEMENTS
ginkgo biloba
echinacea purpurea
chamomile
licorice
canthaxanthine
datura (jimson weed)
niacin
vitamin A

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