October 5, 2020

APL-2 Slows Progression of Early Disease in Patients with Geographic Atrophy

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APL-2 Slows Progression of Early Disease in Patients with Geographic Atrophy

 Apellis Pharmaceuticals, Inc. announced their analysis of the Phase 2 FILLY study investigating intravitreal pegcetacoplan (APL-2) for the treatment of geographic atrophy (GA), also known as advanced dry macular degeneration. The post hoc analysis found that the monthly treatment reduced the rate of progression to GA by 39 percent in areas of the retina outside of existing GA lesions.

APL-2 is the only targeted C3 therapy in Phase 3 clinical trials for GA, a complement-driven eye disease that causes loss of central vision, affects approximately five million people globally and has no approved treatment.

According to SriniVas Sadda, M.D., President & Chief Scientific Officer of the Doheny Eye Institute and lead investigator, “This study provides exciting evidence to support further exploration of the potential of pegcetacoplan for earlier intervention in the course of GA.”

For current information about all major research for treatment of geographic atrophy, see “A Guide to Research in Dry AMD” on this site.

Related earlier articles:

Apellis Entering Phase 3 Trials for Dry Macular Degeneration (2017)

Promising Update on APL-2 for Dry AMD (2015)

SOURCE: News Release

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