Research and Developments

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July 6, 2013

What is a Clinical Trial?

Posted in: Research and Developments

(From “The First Year: Age-Related Macular Degeneration,” (Sep 2006) by Daniel L. Roberts) A clinical trial involves direct observation of a living patient to answer specific questions about vaccines, therapies, or new methods. It is designed in four phases, during which rigorous protocols must be followed under FDA guidelines: Phase I: Determination of safety and
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June 21, 2013

New Anti-PDGF Aptamer Now in Trials

Posted in: Research and Developments

by Dan Roberts February 15, 2008 Ophthotech has begun the first phase of a clinical trial of E10030, an anti-platelet derived growth factor aptamer being developed for treating wet AMD. The trial will evaluate the safety and tolerability of E10030 in combination with an antiangiogenic drug. The hope is that the combination will result in
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June 1, 2013

Summary of Research and Developments in Macular Degeneration, 2012-2013

Posted in: Research and Developments

by Dan Roberts June 2013 INTRODUCTION This is a summary of reports about significant research and development in the field of macular degeneration and related diseases presented since June 2012 and May 2013. I will briefly describe the conclusions of 77 studies that have been presented in the areas of therapy, prevention, technology, nutrition and
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May 30, 2013

A Guide to Research in Dry AMD

Posted in: Research and Developments

Compiled by Dan Roberts (Updated 9/16/18) This is a guide to all leading research to date in the field of dry age-related macular degeneration (AMD). It is divided into three categories: Pharmaceutical Gene Therapy Surgical Intervention Procedures Most headings contain links to further information. Hopefully, this document will help to identify information of interest specifically
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April 6, 2013

How Many People are Legally Blind from Wet AMD?

Posted in: Eye Conditions, Research and Developments

by Dan Roberts April 2013 The latest report I have seen that provides anything close to an accurate estimate of legal blindness among people with wet age-related macular degeneration (AMD) is Wilmer Eye Institute’s “Causes and prevalence of visual impairment among adults in the United States” by Congdon N, et al (Arch Ophthalmol. 2004 Apr;122(4):477-85).
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March 21, 2013

Stem Cells Found in Human Breast Tissue

Posted in: Latest News, Research and Developments

by Dan Roberts In March of 2013, an online early edition of the Proceedings of the National Academy of Sciences reported that newly discovered stem cells from human breast tissue are more genetically stable than the human induced pluripoint stem cells (hiPS cells) currently being developed. In addition to avoiding the issue of using embryonic
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March 8, 2013

Stem Cell Procedures Promising

Posted in: Latest News, Research and Developments

by Dan Roberts (Updated February 20, 2015) Several studies are showing success at using stem cell transplantation to treat retinal degeneration. This article describes the progress of the research. University of Washington In 2006, a team from the University of Washington used a mix of “growth factors”, natural proteins that encourage cell growth, to coax
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December 19, 2012

Aspirin and AMD

Posted in: Research and Developments

by Dan Roberts Updated 12/19/12 This is an attempt to shed some light on the issue of aspirin and macular degeneration. In the spring of 2005, a large study introduced some interesting new information about aspirin. The study was done using 39,876 women over a 10-year period in order to clarify the suspected differences between
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September 27, 2012

Antiangiogenic Drugs Are Stopping Neovascularization in Wet Macular Degeneration

Posted in: Research and Developments

by Dan Roberts A substance in the body called Vascular Endothelial Growth Factor (VEGF) is responsible for the growth of new blood vessels. It promotes this growth by stimulating the endothelial cells, which form the walls of the vessels and transport nutrients and oxygen to the tissues. Evidence shows that when the retinal pigment epithelial
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June 5, 2012

Implantable Miniature Telescope (IMT) For AMD and Stargardt’s Disease

Posted in: Latest News, Research and Developments

by Dan Roberts (Updated: June 5, 2012) The IMT is a micro-sized precision telescope, about the size of a pea, that is implanted in one eye in an outpatient surgical procedure conducted under local anesthesia. The IMT provides magnification of 3.0X or 2.2X, depending on the IMT model used. A magnified image is projected over
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