Research and Developments

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November 4, 2006

Drusen Lasering

Posted in: Research and Developments, Therapies, Treatments, and Procedures

by Dan Roberts (Updated 11/4/06) Drusen are thought to be fatty waste products from the photoreceptor cells. They often appear on the macula (the center of the retina) in the early stages of Macular Degeneration, and they can cause gradual loss of central vision. “Hard” drusen are common in aging eyes, and do not necessarily
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October 15, 2006

Discovery of HTRA1 Gene Provides Potential Marker for AMD

Posted in: Latest News, Research and Developments

by Dan Roberts October 2006 The protein Complement Factor H (CFH) has previously been found to play a role in the development of soft confluent drusen leading to AMD (see “CFH and CFB Proteins May Lead to AMD”). CFH has implicated inflammation as part of the AMD pathogenesis, and now, discovery of a new gene
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July 29, 2006

Abortion Drug Offers Hope for People with Central Serous Chorioretinopathy

Posted in: Research and Developments, Therapies, Treatments, and Procedures

An abortion drug known as ru486 is showing potential as a treatment for central serous chorioretinopathy (CSC), a condition which can lead to loss of central vision. The drug, also called mifepristone, blocks the action of progesterone, a hormone necessary to sustain pregnancy. It is also a potent antiglucocorticoid agent. Glucocorticoids are drugs and hormones
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June 25, 2006

Age-related Macular Degeneration Does Not Cause Blindness

Posted in: Latest News, Research and Developments

A revealing opinion poll sponsored by MD Support shows that a strong majority of people affected by AMD do not think of themselves as blind, and they do not want the term to be used to describe their visual impairment. The pronouncement is well known: “age-related macular degeneration (AMD) is the leading cause of blindness
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June 1, 2006

Summary of Research and Developments in Macular Degeneration: 2005-2006

Posted in: Research and Developments

by Dan Roberts This is a compilation of significant research in the field of macular degeneration during the period May 2005 through May 2006, beginning with new findings as presented at the 2006 meeting of the Association for Research in Vision and Ophthalmology (ARVO). Triple therapy found to be effective for wet AMD Triple therapy
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June 1, 2006

Summary of Research and Developments in Macular Degeneration: 2005-2006

Posted in: Research and Developments

by Dan Roberts This is a compilation of significant research in the field of macular degeneration during the period May 2005 through May 2006, beginning with new findings as presented at the 2006 meeting of the Association for Research in Vision and Ophthalmology (ARVO). Triple therapy found to be effective for wet AMD Triple therapy
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April 20, 2006

Stem Cells Promise Cure

Posted in: Latest News, Research and Developments

by Dan Roberts April 20, 2006 Here is a summary of an article that appeared in Science Magazine regarding stem cell transplantation for treatment of retinal degeneration: Stem Cells Promise Cure For Vision Loss Wednesday, April 19, 2006 New Delhi: Dr Rajender Prasad Centre for Opthalmic Sciences at AIIMS has been studying the effect of stem
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February 22, 2006

Gene Therapy Studies Successful in Slowing Neovascularization

Posted in: Research and Developments

by Dan Roberts January 2002 (Updated February 2006) Researchers at Johns Hopkins’ Wilmer Eye Institute have been able to successfully slow blood vessel growth in laboratory mice in two different experiments involving injection of genes, and human trials have begun. In one study (Mori, K., et al., “Inhibition of Choroidal Neovascularization by Intravenous Injection of
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February 21, 2006

Drusen Fragments May Lead to Wet AMD

Posted in: Research and Developments

by Dan Roberts February 2006 Dr. Jayakrishna Ambati (University of Kentucky HealthCare physician and Associate Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences), has announced that his lab has identified fragments of two known components of drusen that may be the cause of dry age-related macular degeneration (AMD) progressing to the
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January 17, 2006

Gene Therapy Successful in Halting CNV

Posted in: Latest News, Research and Developments

by Dan Roberts Researchers have been able to halt (at least temporarily) choroidal neovascularization (CNV) with gene replacement therapy. This was done by single injections into the eyeballs of patients during a phase I clinical trial. Here is more detail, as reported on January 17, 2006 by Genetic Engineering News (www.genengnews.com): Clinical Trial on Gene
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