Research and Developments

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March 25, 2005

Transpupillary Thermotherapy (TTT) Trials Continue

Posted in: Research and Developments

by Dan Roberts Originally published on MDSupport, updated March 2005 Since March 2000, an experimental study (“Transpupillary Thermotherapy of Occult Subfoveal Choroidal Neovascular Membrane,” or TTT4CNV”) has been underway using transpupillary thermotherapy (TTT) for the treatment of the occult form of age-related macular degeneration (AMD). The therapy utilizes a low dose of infrared laser light
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March 10, 2005

Photrex Trials Show Beneficial Results

Posted in: Latest News, Research and Developments

by Dan Roberts (Updated March 10, 2005) Doctors reported successful results from analyses of Miravant Medical Technologies’ Phase III clinical trials for Photrex (aka rostaporfin or SnET2) on October 25, 2004 at the American Academy of Ophthalmology (AAO) meeting in New Orleans. Photrex is a proprietary photodynamic therapy drug which has been studied in two
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March 4, 2005

Mouse Model Developed for AMD and Stargardt’s Research

Posted in: Latest News, Research and Developments

by Dan Roberts March 2005 A research team at the University of California, San Diego (UCSD) School of Medicine and the University of Utah have developed a mouse model of Age-Related Macular Degeneration (AMD) and Stargardt’s disease. As reported in the online edition of the Proceedings of the National Academy of Sciences (March 4, 2005),
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November 15, 2004

Stem Cells Have Restored Vision

Posted in: Latest News, Research and Developments

by Dan Roberts November 2004 Scientists from Harvard’s Schepens Eye Research Institute have, for the first time, successfully improved the vision of mice with transplanted stem cells. Neural stem (progenitor) cells were obtained from day-old mice and grafted into the degenerating retinas of mature mice. The transplanted cells were then seen to develop into mature
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October 22, 2004

Human Retinal Stem Cells Discovered

Posted in: Latest News, Research and Developments

by Dan Roberts Research in vision restoration has taken another step forward with the discovery of human retinal stem cells that have the ability to regenerate themselves. The announcement was made in October 2004 to the National Academy of Sciences by Derek Van der Kooy from the Department of Medical Biophysics at the University of
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September 15, 2004

Sight From Fetal Cell Transplantation

Posted in: Latest News, Research and Developments

by Dan Roberts January, 2003 (Updated September, 2004) Scientists are researching a new method of retinal transplantation in the continuing effort to restore sight to the blind. Drs. Robert Aramant and Magdalene Seiler (Doheny Eye Institute, Los Angeles) have had preliminary success transplanting double layers of cells from the retinas of aborted fetuses. The two
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July 22, 2004

Second AMD Gene Discovered

Posted in: Latest News, Research and Developments

A second gene, called fibulin 5, has been shown to be related to age-related macular degeneration (AMD). The discovery was announced in the July 22, 2004 issue of the New England Journal of Medicine by a team from the Research Center for Macular Degeneration and Allied Retinal Diseases at the University of Iowa. Earlier research
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February 11, 2004

C-reactive Protein Levels Connected to Macular Degeneration

Posted in: Research and Developments

by Dan Roberts There has been a good deal of excitement about the possible connection between the level of C-reactive protein (CRP) in the blood and various diseases, including macular degeneration. CRP is responsible for the healing benefit of inflammation that occurs when a part of the body is in trouble. If, however, the level
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October 21, 2003

FFB-Sponsored Study Leads to Discovery of New AMD Gene

Posted in: Latest News, Research and Developments

(Press release from the Foundation Fighting Blindness) October 21, 2003 An exciting gene discovery by an FFB-funded researcher adds to the growing proof that macular degeneration can be hereditary. This is the first gene mutation found that is directly tied to age-related macular degeneration (AMD). The discovery of this gene mutation bolsters hope for a
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September 30, 2003

RDH5 Gene Mutation Can Cause Macular Dystrophy

Posted in: Research and Developments

by Dan Roberts September 2003 Japanese researchers have found that mutations in the RDH5 gene can cause macular dystrophy, fundus albipunctatus, and/or night blindness. Twenty-one patients from nineteen different families with fundus albipunctatus were analyzed. Ten of the patients had macular dystrophy. In eighteen, mutations were found in the RDH5. The patients were tested using
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