Research and Developments

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February 22, 2006

Gene Therapy Studies Successful in Slowing Neovascularization

Posted in: Research and Developments

by Dan Roberts January 2002 (Updated February 2006) Researchers at Johns Hopkins’ Wilmer Eye Institute have been able to successfully slow blood vessel growth in laboratory mice in two different experiments involving injection of genes, and human trials have begun. In one study (Mori, K., et al., “Inhibition of Choroidal Neovascularization by Intravenous Injection of
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February 21, 2006

Drusen Fragments May Lead to Wet AMD

Posted in: Research and Developments

by Dan Roberts February 2006 Dr. Jayakrishna Ambati (University of Kentucky HealthCare physician and Associate Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences), has announced that his lab has identified fragments of two known components of drusen that may be the cause of dry age-related macular degeneration (AMD) progressing to the
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January 17, 2006

Gene Therapy Successful in Halting CNV

Posted in: Latest News, Research and Developments

by Dan Roberts Researchers have been able to halt (at least temporarily) choroidal neovascularization (CNV) with gene replacement therapy. This was done by single injections into the eyeballs of patients during a phase I clinical trial. Here is more detail, as reported on January 17, 2006 by Genetic Engineering News (www.genengnews.com): Clinical Trial on Gene
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November 13, 2005

Bacterial Infection Linked to AMD

Posted in: Research and Developments

by Dan Roberts (Updated November 13, 2005) According to a report in the April 2003 issue of the Archives of Ophthalmology (2003;121:478-482.), the bacterium Chlamydia pneumoniae may lead to a higher risk of age-related macular degeneration (AMD). The researchers found that people with AMD tend to carry higher levels of antibodies targeted against C. pneumoniae,
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July 13, 2005

Phototrop Improves Vision in ARMD Patients

Posted in: Latest News, Research and Developments

by Dan Roberts July 13, 2005 Phototrop (a combination of compounds which affect mitochondrial lipid metabolism) is now available in the United States. The compound was reported to yield significant results in a paper published in May 2005. (“Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of
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March 25, 2005

Transpupillary Thermotherapy (TTT) Trials Continue

Posted in: Research and Developments

by Dan Roberts Originally published on MDSupport, updated March 2005 Since March 2000, an experimental study (“Transpupillary Thermotherapy of Occult Subfoveal Choroidal Neovascular Membrane,” or TTT4CNV”) has been underway using transpupillary thermotherapy (TTT) for the treatment of the occult form of age-related macular degeneration (AMD). The therapy utilizes a low dose of infrared laser light
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March 10, 2005

Photrex Trials Show Beneficial Results

Posted in: Latest News, Research and Developments

by Dan Roberts (Updated March 10, 2005) Doctors reported successful results from analyses of Miravant Medical Technologies’ Phase III clinical trials for Photrex (aka rostaporfin or SnET2) on October 25, 2004 at the American Academy of Ophthalmology (AAO) meeting in New Orleans. Photrex is a proprietary photodynamic therapy drug which has been studied in two
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March 4, 2005

Mouse Model Developed for AMD and Stargardt’s Research

Posted in: Latest News, Research and Developments

by Dan Roberts March 2005 A research team at the University of California, San Diego (UCSD) School of Medicine and the University of Utah have developed a mouse model of Age-Related Macular Degeneration (AMD) and Stargardt’s disease. As reported in the online edition of the Proceedings of the National Academy of Sciences (March 4, 2005),
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November 15, 2004

Stem Cells Have Restored Vision

Posted in: Latest News, Research and Developments

by Dan Roberts November 2004 Scientists from Harvard’s Schepens Eye Research Institute have, for the first time, successfully improved the vision of mice with transplanted stem cells. Neural stem (progenitor) cells were obtained from day-old mice and grafted into the degenerating retinas of mature mice. The transplanted cells were then seen to develop into mature
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October 22, 2004

Human Retinal Stem Cells Discovered

Posted in: Latest News, Research and Developments

by Dan Roberts Research in vision restoration has taken another step forward with the discovery of human retinal stem cells that have the ability to regenerate themselves. The announcement was made in October 2004 to the National Academy of Sciences by Derek Van der Kooy from the Department of Medical Biophysics at the University of
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