(Updated 3/12/22) A substance in the body called Vascular Endothelial Growth Factor (VEGF) is responsible for the growth of new blood vessels. It promotes this growth by stimulating the endothelial cells, which form the walls of the vessels and transport nutrients and oxygen to the tissues. Evidence shows that when the retinal pigment epithelial (RPE) [Read More]
Tag: PEDF
Summary of Research and Developments in Macular Degeneration: 2005-2006
by Dan Roberts This is a compilation of significant research in the field of macular degeneration during the period May 2005 through May 2006, beginning with new findings as presented at the 2006 meeting of the Association for Research in Vision and Ophthalmology (ARVO). Triple therapy found to be effective for wet AMD Triple therapy [Read More]
Gene Therapy Studies Successful in Slowing Neovascularization
by Dan Roberts January 2002 (Updated February 2006) Researchers at Johns Hopkins’ Wilmer Eye Institute have been able to successfully slow blood vessel growth in laboratory mice in two different experiments involving injection of genes, and human trials have begun. In one study (Mori, K., et al., “Inhibition of Choroidal Neovascularization by Intravenous Injection of [Read More]
Gene Therapy Successful in Halting CNV
by Dan Roberts Researchers have been able to halt (at least temporarily) choroidal neovascularization (CNV) with gene replacement therapy. This was done by single injections into the eyeballs of patients during a phase I clinical trial. Here is more detail, as reported on January 17, 2006 by Genetic Engineering News (www.genengnews.com): Clinical Trial on Gene [Read More]